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  • Concentration  (1)
  • Key words: Isolated guinea pig trachea—Paper dust extract—Airway reactivity.  (1)
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  • 1
    ISSN: 1432-1750
    Schlagwort(e): Key words: Isolated guinea pig trachea—Paper dust extract—Airway reactivity.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. The effect of paper dust collected at two different locations in a paper recycling plant (PD1 and PD2) on isolated nonsensitized guinea pig tracheal smooth muscle was studied in vitro. Dust extracts were prepared as a 1:10 w/v aqueous solution. Dose-related contractions of guinea pig tracheal rings were elicited with both PD1 and PD2. Pharmacologic studies were performed with atropine (10−6 M), indometacin (10−6 M), pyrilamine (10−6 M), LY171883 (10−5 M), nordihydroguaiaretic acid (10−5 M), and TMB8 (10−5 M). The possible role of endogenous neuropeptides in this constrictor process was studied by depleting neural mediators with capsaicin (5 × 10−6 M) before challenge with dust extracts. Constrictor effects were partially inhibited by a wide variety of the mediator blocking agents. The effects of both extracts were almost totally inhibited by the anticholinergic agent atropine, suggesting that a principal pathway mediating this response may involve the parasympathetic nervous system. The intracellular calcium-blocking agent TMB8 also induced a reduction of the contractile responses to PD1 and PD2 concsistent with the well established role of intracellular calcium in smooth muscle constriction. Pretreatment with capsaicin significantly increased the contractile activity of paper dust extracts but only at the higher doses of these extracts. This suggests that the effect of paper dust is not initiated by the release of mediators stored in sensory nerves but that the prerelease of these mediators may enhance the constrictor effects of these dusts. We suggest that paper dust extracts cause dose-related airway smooth muscle constriction possibly associated with the release of cholinergic as well as other mediators. The constrictor effect does not require tissue presensitization or the release of neuropeptides from sensory nerves.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Plant and soil 52 (1979), S. 345-351 
    ISSN: 1573-5036
    Schlagwort(e): Boron ; Concentration ; Particle track technique ; Plants ; Soil ; Trace elements ; Uranium ; Vegetation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Summary Uranium and boron contents in plant samples along with the representative soil samples collected from the Puga Valley have been estimated by the particle etch technique. The uranium content in soil samples varies from 1.9 to 12.8 ppm with an average of 6.8 ppm and in plant samples from 0.20 to 17 ppm with an average of 3.3 ppm. The boron concentration in soil samples varies from 8.2 to 40.6 ppm with an average of 24.2 ppm and in plants from 17.7 to 42.8 ppm with an average of 27.5 ppm. At higher altitudes (around 4600 meters above the sea level), the typical plant assemblage have a relatively high capacity to absorb uranium and boron from soil. This interrelation and distribution is recorded in the present study.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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