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  • 1
    Electronic Resource
    Electronic Resource
    Cognitive impairments of aphasics in picture sorting and matching tasks (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 232 (1982), S. 223-234 
    Details
    ISSN: 1433-8491
    Keywords: Aphasia ; Laterality ; Cognition (disorders) ; Concept formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract On the basis of earlier experiments showing a differential deficit of aphasics in picture sorting and matching tasks, two experiments were conducted to test the conjecture of a specific deficit of aphasics in the analytical appraisal of individual features. Broca's and Wernicke's aphasics-according to clinical diagnoses and the Aachener Aphasie Test-were compared with patients having right-hemisphere lesions or left-hemisphere lesions without aphasia. Both groups of aphasics differed from the control groups in the sorting task, irrespective of the sorting criterion, but the differences were small. The picture matching task did not discriminate between groups. Obviously, the basic assumption has to be modified with respect to specific conditions of task requirements. The experimental literature is reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02141783
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of a neuron-specific antiserum, BPM, on thein vitro development of cerebellar granule cells (1987)
    Springer
    Cellular and molecular neurobiology 7 (1987), S. 61-71 
    Details
    ISSN: 1573-6830
    Keywords: tissue culture ; development ; neurons ; glia ; D2-cell adhesion molecule (CAM)/N-CAM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Anti-BPM is a neuron-specific antiserum which specifically recognizes the D2 cell adhesion molecule in crossed immunoelectrophoresis of Triton X-100-solubilized brain extracts. Here the effect of this antiserum on thein vitro development of cerebellar neuronal cultures is described. 2. The initial adhesion of cells and neurite outgrowth were not influenced by immunoglobulin fractions of anti-BPM. However, after 5 daysin vitro the cultures had become completely disorganized, with the majority of cells being dead at immunoglobulin concentrations greater than 0.5 mg/ml culture medium. 3. This effect was seen only with immunoglobulins and their F(ab′)2 fragments, the F(ab′) fragments being without effect. The addition of anti-BPM to 8-day-old cultures resulted in a more rapid and pronounced rate of cell death. In many instances this was preceded by a rapid “destabilization” of culture organization. 4. The cytotoxic effect of anti-BPM was neuron specific and the small numbers of astrocytes and fibroblasts found in the cultures were unaffected by prolonged exposure to this serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00734990
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    Paper (German National Licenses)
    Fulltext
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