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  • 1
    Electronic Resource
    Electronic Resource
    The influence of various neuroleptic drugs on shock avoidance responding in rats (1970)
    Springer
    Psychopharmacology 17 (1970), S. 151-159 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Conditioning ; Neuroleptics ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inhibitory effects of four neuroleptic drugs on amphetamineinduced stimulation in a discriminated Sidman avoidance procedure in rats were measured. Amphetamine 0.63 mg/kg s.c. increased R (responses) and decreased W (warning stimuli), WR (warning responses) and S (shocks). Relatively low doses of all four neuroleptics antagonized the amphetamineinduced changes. The order of potency was haloperidol 〉 pimozide 〉 chlorpromazine 〉 pipamperone. The duration of action was pimozide 〉 haloperidol 〉 pipamperone 〉 chlorpromazine. Haloperidol, pimozide and pipamperone restored the amphetamine-induced changes to the initial control levels in the order: S, W, WR and R. With chlorpromazine this order was reversed, except for R. The different pharmacological profiles of haloperidol, pimozide and pipamperone are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402705
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of various neuroleptic drugs on shock avoidance responding in rats (1969)
    Springer
    Psychopharmacology 16 (1969), S. 161-174 
    Details
    ISSN: 1432-2072
    Keywords: Drugs ; Neuroleptics ; Behaviour ; Conditioning ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of twenty neuroleptic drugs on conditioned behaviour was studied in rats by means of a lever-press shock-avoidance procedure (shock-shock 20 sec, response-shock 20 sec). All twenty drugs inhibited lever-press response and reduced the shock-avoidance rate at very low dose levels. The order of potency was: benperidol=spiroperidol 〉 trifluperidol 〉 droperidol=spiramide 〉 clofluperol=fluphenazine=haloperidol=spirilene 〉 moperone 〉 perphenazine 〉 amiperone 〉 fluanisone=trifluperazine 〉 pimozide 〉 thioperazine 〉 chlorpromazine 〉 pipamperone=thioridazine 〉 promazine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02456042
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The influence of various neuroleptic drugs on shock avoidance responding in rats (1969)
    Springer
    Psychopharmacology 16 (1969), S. 175-182 
    Details
    ISSN: 1432-2072
    Keywords: Neuroleptics ; Conditioning ; Extinction ; IRT's ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of seven neuroleptic drugs on conditioned behaviour were studied in rats by means of a lever-press shock-avoidance procedure (shock-shock 20 sec; response-shock 20 sec) with alternate reinforcement and extinction periods. All seven drugs inhibited the lever-press response and the shock-avoidance rate; their order of potency was trifluperidol 〉 droperidol 〉 haloperidol 〉 pimozide 〉 fluanisone 〉 chlorpromazine 〉 pipamperone. For all seven drugs, the response rate during the extinction periods was a more sensitive indicator of drug effect than the response rate during the reinforcement periods. Analysis of the temporal distribution of the IRT's shows that IRT's of 0–5″ and of 6–15″ were more sensitive to drug effects than IRT's of 16–20″ and of 〉 20″. The introduction of extinction periods together with the analysis of IRT's rendered the Sidman avoidance procedure the most sensitive test available for the quantitative evaluation of the potency of neuroleptic drugs in rats. The qualitative differences between the neuroleptics studied were less pronounced. There is some indication, however, that specific neuroleptics (e.g. pimozide) inhibit the response rate to about the same extent during both reinforcement and extinction periods, while aspecific neuroleptics (e.g. pipamperone) are more active inhibitors of the responses during extinction than during the corresponding reinforcement periods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02456043
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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