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  • 1
    ISSN: 1432-2013
    Keywords: Key words Arteries ; Conductivity ; Conductance method ; Double indicator dilution method ; Shear rate ; Intravascular ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A double indicator dilution technique for determining the mean cross-sectional area (CSA) of a blood vessel in vivo is presented. Analogous to the thermodilution method, dilution of hypertonic saline was measured by an electrical conductance technique. Because the change in conductance rather than absolute conductance was used to calculate CSA, pulsatile changes in shear rate of blood and conductance of surrounding tissues had no effect on the data. To calculate CSA from an ion mass balance, cardiac output was needed and estimated from the thermodilution curve using the same “cold” (hypertonic) saline injection. The mean CSA, obtained from this double indicator dilution method (CSAGD), was compared with the CSA obtained from the intravascular ultrasound method (IVUS) in 44 paired observations in six piglets. The regression line is close to the line of identity (CSAGD = −1.83 + 1.06⋅CSAIVUS, r = 0.96). The difference between both CSAs was independent of the diameter of the vessel, on average −0.99 mm2± 2.64 mm2 (mean CSAGD = 46.84 ± 8.21 mm2, mean CSAIVUS = 47.82 ± 9.08 mm2) and not significant. The results show that the double indicator dilution method is a reliable technique for estimating the CSA of blood vessels in vivo.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-9686
    Keywords: Conductivity ; Erythrocytes ; Ultrasound ; Shear stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract A modified conductance method to determine the cross-sectional areas (CSAs) of arteries in piglets was evaluated in vivo. The method utilized a conductance catheter having four electrodes. Between the outer electrodes an alternating current was applied and between the inner electrodes the induced voltage difference was measured and converted into a conductance. CSA was determined from measured conductance minus parallel conductance, which is the conductance of the tissues surrounding the vessel times the length between the measuring electrodes of the conductance catheter divided by the conductivity of blood. The parallel conductance was determined by injecting hypertonic saline to change blood conductivity. The conductivity of blood was calculated from temperature and hematocrit and corrected for maximal deformation and changes in orientation of the erythrocytes under shear stress conditions. The equations to calculate the conductivity of blood were obtained from in vitro experiments. In vivo average aortic CSAs, determined with the conductance method CSA (G) in five piglets, were compared to those determined with the intravascular ultrasound method CSA(IVUS). The regression equation between both values was CSA (G) =−0.09+1.00·CSA(IVUS) r=0.97, n=53. The mean difference between the values was −0.29% · 5.57% (2 standard deviations). We conclude that the modified conductance method is a reliable technique to estimate the average cross-sectional areas of the aorta in piglets. © 1999 Biomedical Engineering Society. PAC99: 8780-y, 8437+q, 8719Nn
    Type of Medium: Electronic Resource
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