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  • 1
    Electronic Resource
    Electronic Resource
    Collagenase for Peyronie's disease experimental studies (1982)
    Springer
    Urological research 10 (1982), S. 135-140 
    Details
    ISSN: 1434-0879
    Keywords: Peyronie's Disease ; Clostrideal collagenase ; Connective tissue ; Collagen ; Injection therapy ; Scar dissolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This pilot study was designed to test the feasibility of using purified clostridial collagenase in the clinical management of Peyronie's disease. The basic properties of this agent are discussed. We studied its effect on Peyronie's plaque tissue by a quantitative in vitro assay utilising the liberation of free α-amino groups as an index of enzymatic collagenolysis. Tissue from three patients with Peyronie's disease was used. Tunica albuginea from a second group of three normal patients was studied in the same manner, and no selectivity for the collagen of Peyronie's plaques was identified. Utilising human pericardium as a uniform collagenous substrate, a simple dose-effect relationship was established, and the distribution characteristics of injected collagenase observed. Its effects on blood vessels and nerves in vivo was determined as well as the effects of collagenase on the histology of normal and diseased human tissue in vitro. A tentative dose for use in Peyronie's disease was established, which is discussed in light of existing toxicological data. The study was designed to test the eeasibility of purified collagenase in the clinical management of Peyronie's disease. Data included detail plaque digestion and dose-effect relationships in vitro, as well as the histological effects on plaques, blood vessels, and nerves in vivo and in vitro. It is concluded that collagenase may warrant further clinical testing in the treatment of Peyronie's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255956
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  • 2
    Electronic Resource
    Electronic Resource
    Human Gallbladder Mucosal Function (Effects on Intraluminal Fluid and Lipid Composition in Health and Disease) (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 335-343 
    Details
    ISSN: 1573-2568
    Keywords: GALLBLADDER MUCOSA ; MUCOSAL FLUID ABSORPTION ; LIPID ABSORPTION ; CHOLESTEROL GALLSTONES ; OBESITY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gallbladder mucosal absorption of fluid duringfasting is a well-known process. Indirect in vivo andrecent in vitro evidence for physiologically relevantgallbladder absorption of cholesterol and phospholipids from bile has been observed in humans. Thepresent study explored and compared by indirect meansthe relative efficiences of human gallbladder mucosalabsorption of fluid and lipids in health and disease. Biliary lipids and pigment content weremeasured in fasting gallbladder bile samples obtainedfrom gallstone-free controls and from four study groups:multiple and solitary cholesterol gallstone patients, and morbidly obese subjects with and withoutgallstones. Bile salts and pigment content weresignificantly greater in gallstone-free controls than inall other disease study groups. This was interpreted as evidence of more effective gallbladdermucosal fluid absorption in nonobese gallstone-freecontrols compared to that in all other groups.Correlation plot analyses of biliary lipids showed lowerconcentrations of phospholipids than expected from the indexbile salt concentrations. The same was found forcholesterol concentrations but only in supersaturatedsamples. These findings were much more pronounced in gallstone free-controls and were accordinglyinterpreted as evidence of more efficient gallbladderabsorption of both phospholipids and cholesterol incontrols compared with that found in each of the disease study groups. Moreover, impaired gallbladdermucosal function, while invariably associated withcholesterol gallstone disease, was not found to be anecessary consequence of the physical presence ofstones. It is concluded that efficient gallbladdermucosal absorption of both fluid and apolar lipids frombile is a normal physiological process that is oftenseriously impaired in the presence of either cholesterol gallstone disease or at least one of itsprecursor forms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018858406560
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    Paper (German National Licenses)
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