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Digitale Medien

Increased glucose carbon recycling in severely insulin deficient Type 1 (insulin-dependent) diabetic subjects (1990)

Benn, J. J. ; Rai, R. ; Sönksen, P. H.

Springer

Diabetologia 33 (1990), S. 158-162

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ISSN: 1432-0428

Schlagwort(e): Diabetes mellitus ; insulin-dependent ; glucose recycling ; glucose ; insulin ; Cori cycle ; isotopes

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Six Type 1 (insulin-dependent) diabetic subjects were studied in order to determine the contribution of recycling of glucose carbon to the overproduction of glucose which is characteristic of the fasting hyperglycaemia produced by insulin withdrawal. The subjects were studied on two occasions, once after an overnight insulin infusion and once following 24 h of insulin withdrawal. The difference in turnover rates of 1-14C-glucose and 3-3H-glucose was used as a measure of glucose recycling. Insulin withdrawal caused a marked metabolic derangement with a rise in non-esterified fatty acids from 0.69±0.23 to 1.11±0.21 mmol/l (mean±SEM, p〈0.05), total ketones from 0.27±0.06 to 2.06±0.51 mmol/l (p〈0.01), cortisol from 341±43 to 479±31 nmol/l (p〈0.05) and growth hormone from 1.1±0.3 to 19+5-mu/l (p〈0.05). Glucose turnover rose from 13.8±2.3 μmol·kg−1·min−1 at a glucose of 6.9±0.7 mmol/l in the insulin infused study to 25.8±4.4 μmol·kg−1·min−1 (p〈0.05) at a glucose of 16.4±0.7 mmol/l in the insulin withdrawn study. Recycling also rose from 3.0±0.4 μmol· kg−1·min−1 to 9.4±2.2 μmol·kg−1·min−1 (p〈0.05) when insulin withdrawn, accounting for 23±3% and 36±3% of glucose turnover, respectively. We conclude that in the severely insulin deficient Type 1 diabetic subject recycling of glucose carbon is a major contributor to the excess glucose production.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00404043

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Digitale Medien

Strain-specific salt tolerance and chemotaxis ofAzospirillum brasilense and their associative N-fixation with finger millet in saline calcareous soil (1991)

Rai, R.

Springer

Plant and soil 137 (1991), S. 55-59

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ISSN: 1573-5036

Schlagwort(e): Azospirillum brasilense ; chemotaxis ; Eleusine coracana ; nitrogenase activity ; root exudates ; salt tolerant

Quelle: Springer Online Journal Archives 1860-2000

Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft

Notizen: Abstract Three salt-tolerantAzospirillum brasilense strains were isolated from the roots of finger millet grown in saline calcareous soil and characterized. The effect of various salts on growth and N2ase activity of these strains was tested and strain STR1 was found more tolerant at higher concentrations of Cl-, SO4 2 and HCO3 -. Bicarbonate was found to be the most toxic. The content and concentrations of root exudates of finger millet genotypes were different and chemotaxis to sugars, amino acids, organic acids and root exudates was strain specific. Under salt stress, significant interactions between strains and genotypes of finger millet resulted in different responses of N2ase activity, endo- and exorhizospheric population, dry weight of root, shoot and grain yield.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02187432

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