ISSN:
1432-1246
Keywords:
Lead
;
Protoporphyrin in erythrocytes
;
Lead in blood
;
Lead in urine
;
Chelatable lead
;
Correlation
;
Nonlinear regression
;
Validity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The relationship between FEP and the indicators of an internal dose of lead (PbB, PbU, PbU-EDTA) was considered in a group of adult male subjects with varying lead exposure, whose PbB values ranged from 15 – 150 μg/100 ml; a highly significant correlation was found between FEP and PbB, PbU, and PbU-EDTA (r = 0.904; r = 0.889; r = 0.894, respectively). The regression curves representing the relationship between the erythrocyte metabolite and the indicators of internal dose are uniform and are of nonlinear (logistic) type. In the first stage, within the range of normal values (up to 46 μg/100 ml RBC), FEP increases moderately with the rise of internal dose; subsequently it increases exponentially and tends finally to an asymptotic value in the range 250 – 300 μg/100 ml RBC. The data obtained in our investigation suggest that FEP is a useful test to assess metabolic damage in adult subjects arising from an “abnormal” lead absorption and to evaluate the amount of “active deposit” of the metal present in the body. Validity analysis showed that the erythrocyte metabolite can reliably be used as a screening test for monitoring occupationally exposed subjects and can also be applied in general population studies, since FEP has a good validity in the PbB range of 40 – 70 μg/100 and in the PbU-EDTA range of 500 – 2000 μg/24 h.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00378055
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