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  • Corticosteroids  (1)
  • Elective lymph node dissection  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Phospholipase A2 is secreted by murine keratinocytes after stimulation with IL-1α and TNF-α (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 147-152 
    Details
    ISSN: 1432-069X
    Keywords: Key words Phospholipases A ; Epidermal inflammation ; Keratinocytes ; Cytokines ; Corticosteroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phospholipase A 2 (PLA 2 )-catalysed liberation of arachidonic acid is the rate-limiting step in the generation of the lipid mediators prostaglandins and leukotrienes. PLA 2 regulation thus represents a pivotal mechanism in the pathogenesis of inflammation. In this study we investigated the effects of TNFα and IL-1α on PLA 2 activity in cultured murine keratinocytes. Starting 18 h after stimulation, PLA 2 activity increased significantly by about 250–320%) in the supernatants and in the cell pellets. This effect was completely inhibited either by preincubation of the cells with dexamethasone 48 h before stimulation or by coincubation with actinomycin D. PLA 2 acitivty detected in the supernatants was blocked by reduction with dithiothreitol, whereas the PLA 2 activity in the pellets was dithiothreitol-resistant. We conclude that in murine keratinocytes IL-1α induce de novo synthesis and release of a secretory PLA 2 and the induction of a different PLA 2 activity in the cytosol. These findings indicate a crucial link betweeen early cytokine effects and the initiation of the lipid mediator cascade in keratinocytes. The observation that PLA 2 induction could be completely inhibited by preincubation with dexamethasone allows new insights into the mechanism of steroid effects on epidermal inflammation and renders PLA 2 regulation an interesting therapeutic target.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050037
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Should elective lymph node dissection be used for treatment of primary melanoma? (1989)
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 470-473 
    Details
    ISSN: 1432-1335
    Keywords: Elective lymph node dissection ; Melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A bicenter study compared survival probability in patients with malignant melanoma clinical stage I, treated by wide excision only or wide excision with elective lymph node dissection (ELND). ELND improved the survival only in men with primary tumors of 1.51–3.0 mm thickness. In female patients those without ELND showed a better survival. Thus, the total group of patients did not benefit from ELND, i.e. its value for the improvement of survival from malignant melanoma stage I could not be statistically proven.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393340
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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