ISSN:
1432-0428
Keywords:
Virus-induced diabetes
;
Coxsackie B4 virus
;
Coxsackie B3 virus
;
islet cell damage
;
CD1 mice
;
pancreas
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Diabetes was induced in 20–30% of adult CD1 mice 15–20 days after infection by a tissue culture propagated strain of Coxsackie B4 virus. Serum insulin and insulin release from isolated islets indicated a relative insulin deficiency in diabetic animals. In some animals diabetes appeared to be permanent whilst in many it was of a temporary nature. Histology showed only slight damage in both islet and acinar tissue. Infection with pancreas and heart adapted strains of Coxsackie B3 virus failed to produce diabetes in mice and, in contrast to the effects of Coxsackie B4, severe acinar cell damage was seen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01219537
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