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  • 1
    Electronic Resource
    Electronic Resource
    Prediction of type 1 diabetes mellitus—a report on three cases (1985)
    Springer
    European journal of pediatrics 143 (1985), S. 175-178 
    Details
    ISSN: 1432-1076
    Keywords: Juvenile diabetes mellitus ; Child ; Pre-diabetic state ; Autoantibodies ; Histocompatibility antigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In three children (patients 1, 2 and 3) insulindependency was predicted 28, 32 and 4 months, respectively before the disease became clinically manifest, by the finding of islet cell antibodies at that time. These retrospective findings support the evidence for a long pre-diabetic phase in childhood diabetes, marked by the presence of islet cell antibodies, as well as the linkage of HLA-antigens to the susceptibility to this disease. The possibility of detecting pre-diabetic states in children before the endogenous insulin secretion decreases to the point of producing clinical symptoms support efforts by basic scientists to develop techniques for immunological intervention early in the course of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442131
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Associated anomalies in undescended testes (1982)
    Springer
    European journal of pediatrics 139 (1982), S. 272-274 
    Details
    ISSN: 1432-1076
    Keywords: Cryptorchidism ; Chromosomal abnormalities ; Congenital defects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several chromosomal and nonchromosomal syndromes are associated with cryptorchidism. Primary dysgenetic hypogonadism probably is the major cause of cryptorchidism in these syndromes. Systematic microscopic investigations of testicular tissue are not available. testicular tissue are not available. A higher than normal incidence of urinary tract malformations in boys with cryptorchidism has been reported, but there is no agreement in the literature on whether all patients with cryptorchidism should be screened for abnormalities of the urinary tract. In infants with ambiguous genitalia, including hypospadias, very often the testes are not palpable. Extensive evaluation of such infants is a ‘social emergency’; early assignment of the gender role of the infant is of great importance. The association of neurofacial midline defects with short stature and cryptorchidism should be recognized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442178
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    LH-RH nasal spray treatment for cryptorchidism (1987)
    Springer
    European journal of pediatrics 146 (1987), S. S35 
    Details
    ISSN: 1432-1076
    Keywords: Cryptorchidism ; Testis ; Synthetic hormones ; LH-RH ; LH-FSH releasing hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A double-blind, placebo-controlled study of the efficacy of LH-RH nasal spray in treatment of cryptorchidism involving 252 prepuberal boys with 301 undescended testes, showed a success rate of 9% (14 testes) for LH-RH and 8% (10 testes) for placebo. Including a subsequent open study and a second course of LH-RH as required, the rate for LH-RH rose to 18% (48 testes). The follow-up period saw late descent in another 5% (14 testes), in a few cases coinciding with the onset of puberty. Retrospective evaluation revealed a previous scrotal position of the testes for 43% of the boys with success of treatment and even for 17% of the boys with failure of treatment. In many of these cases surgery revealed an anatomical anomaly that might have caused testicular ascent. Hormonal evaluation revealed no abnormalities in cryptorchid boys compared with control subjects, nor was there a divergence in values before and after treatment. The lower the pretreatment testicular position, the better the rate of success.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00452867
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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