ISSN:
1434-0879
Keywords:
Alkali citrate
;
Calcium oxalate
;
Crystal growth
;
Human urine
;
Prophylactic treatment
;
Urolithiasis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In this study, an efficient microtechnique (gel crystallization method) was used to investigate the in-vivo effect of sodium-potassium citrate on the crystal growth rate of calcium oxalate (Vcr) in human urine samples of 6 healthy volunteers. With a daily dose of 3x11 mmol of alkali citrate, Vcr decreased by 70%. This could have been due to the decrease of calcium excretion, which caused 50–60% of the total change, and to the increase of citrate and pH, each contributing about 20–25% to the decline of Vcr. The findings explain the clinical advantages of alkali citrates in the prevention of recurrent calcium oxalate stone formation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00294572
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