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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 771 (1984), S. 245-248 
    ISSN: 0005-2736
    Keywords: (E. coli) ; Ion flux ; K^+ ; Rb^+ ; Virus infection
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Lupus erythematodes ; Kutane Manifestationen ; Einteilung ; Klinische Symptomatik ; Sonderformen ; Keywords Lupus erythematosus ; Cutaneous manifestations ; Classification ; Clinical symptoms ; Distinct subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Lupus erythematosus (LE) is a disease with a wide spectrum of cutaneous and systemic manifestations and has been the subject of many studies over several decades. Clinical features of patients with LE show a great variation, and for this reason it is difficult to develop a unifying concept of this disease. Consequently, this has led to the identification of subsets which have been defined by constellations of clinical and photobiological features, histological changes as well as laboratory abnormalities. Besides the characteristic classical forms such as systemic LE (SLE), subacute cutaneous LE (SCLE), and discoid LE (DLE), there are uncommon variants of LE which often lead to diagnostic difficulties. Bullous LE (BLE) and urticarial vasculitis are listed as characteristic but non-specific manifestations of systemic LE. LE tumidus (LET), LE hypertrophic/verrucous (LEHV), chilblain LE, and LE profundus (LEP) are uncommon subtypes of chronic cutaneous LE. Annular erythema and papulonodular mucinosis are further uncommon cutaneous manifestations of LE. This clinical review summarizes the typical features of the uncommon forms of LE in order to improve clinical diagnostic precision and to achieve a better differentiation of the subtypes.
    Notes: Zusammenfassung Der Lupus erythematodes (LE) ist eine Erkrankung, die ein breites Spektrum von kutanen und systemischen Manifestationen aufweist und seit vielen Jahrzehnten die medizinische Wissenschaft beschäftigt. Die große Vielfalt der klinischen Befunde erlaubt es nicht, ein einheitliches Krankheitsbild zu definieren, so dass eine Klassifikation verschiedener Subtypen, die sich bezüglich klinischer, photobiologischer, histologischer und serologischer Merkmale unterscheiden, eingeführt wurde. Neben den gut definierten klassischen Formen wie systemischer LE (SLE), subakut kutaner LE (SCLE) und diskoider LE (DLE) gibt es seltene Manifestationen, die immer wieder diagnostische Schwierigkeiten bereiten. Der bullöse LE (BLE) und die Urtikariavaskulitis werden als charakteristische, aber nicht spezifische Manifestationsformen des systemischen LE aufgeführt. Der LE tumidus (LET), der LE hypertrophicus/verrucosus (LEHV), der Chilblain LE und der LE profundus (LEP) werden als seltene Subtypen des chronisch kutanen LE betrachtet. Das anuläre Erythem und die papulöse Muzinose werden als weitere seltene kutane Manifestationsformen des LE beschrieben. In dieser klinischen Übersicht werden die charakteristischen Merkmale dieser seltenen Sonderformen des LE herausgestellt, um zum weiteren Verständnis und zur genaueren Differenzierung der verschiedenen Subtypen beizutragen.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1912
    Keywords: Thromboxane A2 (TXA2) ; Prostacyclin (PGI2) ; Human platelets ; Bovine coronary artery ; Non-steroidal antiinflammatory drugs ; Prostaglandin-cyclooxygenase ; Bioassay ; RCS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The action of the non-steroidal antiinflammatory drugs indomethacin, tiaprofenic acid, diclofenac and meclofenamate on vascular and plateletcyclooxygenases was studied by measuring the arachidonic acid-induced thromboxane A2 (TXA2)-formation of washed human platelets and prostacyclin (PGI2)-formation of bovine coronary artery rings. TXA2 was bioassayed as RCS on rabbit aorta strips, PGI2 in terms of its antiaggregatory activity on ADP-induced aggregation of human platelet-rich plasma. All of the substances studied produced concentration-dependent inhibition of PGI2- and RCS-release. The IC50 [μM] in inhibition of RCS-formation was 0.019 for indomethacin, 0.070 for tiaprofenic acid but 44.9 for meclofenamate and 63.2 for diclofenac. The IC50 [μM] in inhibition of PGI2-release was 0.42 for diclofenac, 0.63 for indomethacin and 0.99 for tiaprofenic acid. The data suggest (1) high sensitivity of human platelet-cyclooxygenase against indomethacin and tiaprofenic acid, (2) different sequence of the substances studied in inhibiting arachidonic acid-induced TXA2- and PGI2-formation. The possible therapeutic value of selective inhibition of platelets and vascular cyclooxygenases in discussed.
    Type of Medium: Electronic Resource
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