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  • 1985-1989  (2)
  • Cyclodextrin polymer  (1)
  • Lysosomal enzymes  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Progression in nemaline myopathy (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 484-491 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Nemaline myopathy ; Lysosomal enzymes ; Acid phosphatase ; Cathepsins ; Myofibrillar degeneration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Four of seven patients with nemaline myopathy had severe, rapidly progressing symptoms. These four showed an increase in acid phosphatase activity in muscle fibers demonstrated by histochemistry and cathepsin B&L activity by biochemical measurement. On electron microscopy, nemaline bodies, occasionally disorganized myofibrils and autophagic vacuoles containing sarcoplasmic debris and glycogen particles were seen. Focal myofibrillar degeneration, through an unknown pathogenetic mechanism, induces an increase in lysosomal enzymes in the skeletal muscles which may be closely correlated with a rapid aggravation of muscle weakness in nemaline myopathy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687709
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Water soluble cyclodextrin polymers: Their interaction with drugs (1987)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 5 (1987), S. 427-431 
    Details
    ISSN: 1573-1111
    Schlagwort(e): Cyclodextrin polymer ; solubility method ; complex stability ; NMR spectroscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The complex forming ability of a water-soluble β-cyclodextrin epichlorohydrin, polymer (CDPS) and its different molecular weight fractions was studied and compared with the complexing properties of β-cyclodextrin (βCD) and dimethyl-βCD (DM-βCD). CDPS was separated into two main fractions. CDPS and its fractions formed well soluble inclusion compounds with the studied drugs. The low molecular weight fraction formed rather stable complexes with small guest molecules, the high molecular weight fraction was found to be more efficient in binding larger substrates. Structural studies of furosemide-CD complexes were attempted by NMR spectroscopy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00664098
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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