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  • 1
    Electronic Resource
    Electronic Resource
    Phylogenetic relationships within the class Oligohymenophorea, phylum Cilophora, inferred from the complete small subunit rRNA gene sequences ofColpidium campylum, Glaucoma chattoni, andOpisthonecta henneguyi (1991)
    Springer
    Journal of molecular evolution 33 (1991), S. 163-174 
    Details
    ISSN: 1432-1432
    Keywords: Small subunit rRNA ; Ciliophora ; Phylogeny ; Colpidium ; Glaucoma ; Opisthonecta ; Maximum parsimony ; Distance matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Phylogenetic relationships within the class Oligohymenophorea, phylum Ciliophora, were investigated by determining the complete small subunit rRNA (SSrRNA) gene sequences for the hymenostomesColpidium campylum, Glaucoma chattoni, and the peritrichOpisthonecta henneguyi. The affiliations of the oligohymenophoreans were assessed using both distance matrix (DM) and maximum parsimony (MP) analyses. Variations do exist in the phylogenies created by the two methods. However, the basic tree topologies are consistent. In both the DM and MP analyses the hymenostomes (C. campylum, G. chattoni, and the tetrahymenas) all form a very tight group associated with the peritrichO. henneguyi. TheTetrahymena lineage was monophyletic whereasColpidium andGlaucoma were more closely related to each other than either was to the tetrahymenas. The monophyly of the genusTetrahymena in the present analysis supports the phylogenies determined from morphological data and molecular sequence data from the histone H3II/H4II region of the genome. The perplexing and controversial phylogenetic position of the peritrichs is once again depicted in the present analysis. The distinctiveness of the peritrichOpisthonecta from both hymenostome and nassophorean ciliates based on evolutionary distances suggests that the elevation of the peritrichs to a higher taxonomic rank should be reconsidered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02193631
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  • 2
    Electronic Resource
    Electronic Resource
    A clinical trial of cyclosporine G in cadaveric renal transplantation (1995)
    Springer
    Pediatric nephrology 9 (1995), S. S49 
    Details
    ISSN: 1432-198X
    Keywords: Cyclosporine G ; Cadaveric transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cyclosporine G (OG 37-324) reportedly is an efficacious immunosuppressant with less nephrotoxicity than cyclosporine A. This is a prospective randomized double-blinded trial comparing cyclosporine G and cyclosporine A in cadaveric renal transplantation. Patient and graft survival, as well as major infectious complications, were not different between the two groups. Objective parameters of renal function, including serum creatinine, creatinine clearance, and inulin clearance, were routinely performed. These generally demonstrated less nephrotoxicity in those patients treated with cyclosporine G compared with cyclosporine A. Minor elevations of alanine aminotransferase were noted in the cyclosporine G-treated patients but this was not associated with acute morbidity. Overall, cyclosporine G appears to be equally as effective as cyclosporine A, but demonstrated notably less nephrotoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00867684
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    Paper (German National Licenses)
    Fulltext
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