ISSN:
1432-1459
Keywords:
Neuropathy
;
Paraproteinemia
;
Cold agglutinin
;
Anti-Pr2 antibody
;
Ganglioside
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A case of ataxic neuropathy associated with IgMκ M proteinemia is reported. Double filtration plasmapheresis effectively treated the neuropathy. The IgMκ antibody had anti-Pr2 cold agglutinin activity. We demonstrated reactivities of the IgMκ antibody to sialosyl paragloboside, sialosyl lactosaminyl paragloboside, GT1b, GD1a, GD1b, GM3 and GD3 on high-performance thin-layer chromatography immunostaining and enzyme-linked immunosorbent assay, which is previously unreported antigenic specificity of the M proteins in cases of para proteinemic neuropathy. IgM M protein with anti-Pr2 cold agglutinin activity may play a pathogenetic role in peripheral nerve demyelination, because the target antigens of the M protein are present in myelin and possibly in endothelial cells of the peripheral nervous system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00833915
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