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  • 1
    ISSN: 1434-0879
    Schlagwort(e): Key words Gamma-linolenic acid ; Superficial bladder cancer ; Intravesical therapy ; Cytotoxicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The essential fatty acid gamma-linolenic acid (GLA) is an effective cytotoxic agent when applied topically and for prolonged periods to tumour cells. Topical application, by intravesical therapy, is firmly established in the treatment of superficial bladder cancer. However, this form of therapy is limited to a maximum duration of 2 h. At such a short drug exposure time, does GLA retain its cytotoxicity? We have examined this question by exposing the superficial bladder cancer cell lines MGH-U1 and RT112 to meglumine-GLA (MeGLA) for time intervals ranging from 30 min to 2 h, at drug concentrations ranging from 1000 to 1.95 μg/ml. The MTT viable biomass assay was used to assess cell kill. Greater than 90% inhibition was observed at a concentration of 125 μg/ml (IC 〉 90), at 2 h drug exposure. At shorter drug exposure times, higher drug concentrations were needed to induce the same effect. At 1 h drug exposure, the IC 〉 90 was recorded at 500 μg/ml. In vivo intravesical tolerance studies were conducted in rats. Rats exposed to 2.5 mg/ml MeGLA intravesically for 2 h or less remained well and bladder histology showed minimal changes. This study confirms that GLA retains its cytotoxicity at short drug exposure times and is well tolerated by normal bladder mucosa in vivo. Bladder mucosa tolerated 〉10× the concentration required for the IC 〉 90 in vitro. MeGLA is therefore a feasible intravesical agent for superficial bladder cancer.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Intensive care medicine 18 (1992), S. 433-436 
    ISSN: 1432-1238
    Schlagwort(e): Gangrene ; disseminated intravascular coagulation ; Epoprostenol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The syndrome of symmetrical peripheral gangrene is characterised by distal ischaemic damage in two or more extremities, without large vessel obstruction. Four patients with bilateral pedal ischaemia are described and their haemodynamic profiles presented. In all four cases the syndrome developed in association with noradrenaline administration, sepsis and DIC, despite a high cardiac output and a low calculated systemic vascular resistance index. Early treatment with epoprostenol was instituted in the final case and was successful.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    International journal of biometeorology 42 (1998), S. 10-15 
    ISSN: 1432-1254
    Schlagwort(e): Key words Remote sensing ; Maize ; Regional production assessments ; Satellite ; Crop Moisture Index
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geographie , Physik
    Notizen: Abstract  Large-scale assessments of crop conditions prior to harvest are critical for providing early estimates of production. Satellite and weather information provide the opportunity for near real-time crop monitoring. The objective of this research was to develop an operational assessment system for crop production utilizing data from these sources. Maize (Zea mays) production was assessed in 42 Crop Reporting Districts (CRDs) across the United States Corn Belt, which produce 60% of all maize grown in the United States. Satellite, climatolocal, and agricultural data were collected for 8 years, 1985–1992, and aggregated into CRDs. A model predicting the normalized maize yields for each CRD was developed that included as independent variables a satellite data variable, the Vegetation Condition Index, and a climatological variable, the Crop Moisture Index. This model explained approximately three-quarters (R 2=0.73) of the variation observed in the normalized yields, and was examined both for its accuracy and its timeliness in providing production estimates. Predicted seasonal yields were summed to provide a maize production estimate for the entire Corn Belt study region. Production estimates deviated from the final USDA statistics, which become available several months after harvest, by less than 10% for all eight growing seasons. In addition, the production estimates were available approximately 2 months prior to the completion of the maize harvest. This system has the potential for providing timely in-formation to organizations monitoring regional or global agricultural production for humanitarian or economic benefits.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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