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Tumor-promoting activity and cytotoxicity of 3,4,3′,4′-tetrachlorobiphenyl on N-nitrosomorpholine-induced murine liver foci (1989)

Kobusch, A. -B. ; Fischer, G. ; Bock, K. W.

Springer

Journal of cancer research and clinical oncology 115 (1989), S. 247-252

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ISSN: 1432-1335

Keywords: N-Nitrosomorpholine ; 3,4,3′,4′-Tetrachlorobiphenyl ; Tumor promoter ; Cytotoxicity ; Mouse hepatocarcinogenesis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Effects of 3,4,3′,4′-tetrachlorobiphenyl (TCB) on glucose-6-phosphatase (G6Pase)-altered hepatic foci of N-nitrosomorpholine (NNM)-treated B6C3F1 mice were investigated. TCB was chosen as a selective 3-methylcholanthrene-type inducer and tumor promoter. To initiate hepatocarcinogenesis, mice were treated with NNM (160 mg/l, in drinking water for 7 weeks), as in previous studies with the rat model. After a treatment-free interval of 22 weeks, TCB was administered (5×50 mg/kg, every 3 days), and liver foci were analysed 10 weeks after the start of TCB treatment. Unexpectedly, the number of G6Pase-negative and-positive foci per liver was markedly diminished following TCB treatment (to 32% and 57%, respectively). On the other hand, the mean volume of the remaining G6Pase-altered foci was enhanced, owing to an increase in the percentage of foci of large size (〉0.5mm2). Throughout the experimental period of 39 weeks prolonged liver injury due to NNM and TCB treatment was demonstrated by histology and by elevated serum levels of glutamate-oxaloacetate transaminase. The results suggest that (in contrast to the rat system) TCB exhibited opposing effects on liver foci in the mouse model: (a) moderate tumor-promoting effects and (b) cytotoxic effects in NNM-injured liver, leading to decreased numbers of liver foci.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00391697

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[a]-Anellated carbazoles with antitumor activity: Synthesis and cytotoxicity (1996)

Rogge, M. ; Fischer, G. ; Pindur, U. ; [et al.]

Springer

Monatshefte für Chemie 127 (1996), S. 97-102

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ISSN: 1434-4475

Keywords: 3-Vinylindoles ; Carbazoles ; Diels-Alder reactions ; Cytotoxicity

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Zusammenfassung Die aus den methoxysubstituierten 3-Vinylindolen1 und2 zugänglichen Cycloaddukte3,5 und7 lassen sich mitDDQ zu den coplanar-anellierten Carbazolen4,6 und8 dehydrieren. Verbindung4a, die auch durch eine Röntǵenstrukturanalyse charakterisiert wurde, zeigt signifikante Cytotoxizität gegen Humantumor-Zellinien (K562 und RXF93).

Notes: Summary The cycloadducts3,5, and7, readily available from methoxy-substituted 3-vinylindoles1 and2, were dehydrogenated withDDQ to the coplanar [a]-anellated carbazoles4,6, and8. Compound4a, also characterized by X-ray structural analysis, shows significant cytotoxicity against K562 und RXF393 human tumor cell lines.