ISSN:
1434-4726
Keywords:
Pituitary tumours
;
DNA
;
Histopathology
;
Aneuploidy
;
Hormone secretion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The DNA contents of 29 histologically and ultrastructurally benign pituitary tumours were analyzed with flow-cytofluorometry. — Cytogenetic malignancy, i.e., aneuploidy, was found in 12 cases, independent of endocrinological type of tumour. In 17 cases a diploid DNA content occurred. In aneuploid tumours varying percentage of cells in S-phase was found indicating different growth patterns. Aneuploid DNA pattern was often found in young patients with a short case history. Our findings indicate that analysis of cellular DNA content may reflect the biological properties of pituitary tumours, independent of morphologic characteristics and type of hormone secretion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00665373
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