ISSN:
1432-1335
Keywords:
Oxygen radicals
;
DNA damage
;
Poly(ADP-ribose)polymerase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Treatment of cultured mammalian cells with hydrogen peroxide results in the production of extensive DNA damage. Strand breakage was produced at the level of either nascent or mature DNA and the former target appeared slightly more resistant than the latter. Although inhibitors of the enzyme poly(ADP-ribose) polymerase similarly retarded the repair of such lesions, removal of DNA strand breaks was much slower for the newly synthesized DNA as compared to mature DNA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01211801
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