ISSN:
1433-0350
Keywords:
Neurofibromatosis
;
Genetic linkage
;
DNA markers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The von Recklinghausen neurofibromatosis (NF1) gene has been mapped to the pericentromeric region of chromosome 17 and various DNA markers have been identified in this region. We have performed a genetic analysis using an anonymous DNA marker, HHH202 (D17S33), tightly linked to the NF1 gene in seven NF1 Italian families. Only one family was fully informative for the HHH202/RsaI polymorphism. In this family this marker can be used for presymptomatic and prenatal diagnosis. However, it is necessary to use additional flanking markers in order to increase informativeness and to obtain better diagnostic accuracy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00247864
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