ISSN:
1432-0584
Keywords:
ITP
;
CFU-Meg
;
DNA synthetic phase
;
Megakaryocyte
;
Platelet
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The number and proliferative state of megakaryocyte progenitor cells (CFU-Meg) were compared between 13 patients with idiopathic thrombocytopenic purpura (ITP) and hematologically normal controls. The mean frequency of CFU-Meg assayed by the plasma clot method was 27.8 ± 12.2 (± SD)/2×105 bone marrow light-density cells for the ITP patients, which did not differ significantly from the control value of 31.9 ± 16.1. The percentage of CFU-Meg in DNA synthesis estimated by the3H-thymidine suicide technique was 41.3% ± 9.2% in ITP, which was significantly greater than the control value of 27.1% ± 7.4% (P 〈 0.01). The megakaryocyte counts for histological sections prepared from bone marrow aspirates from the ITP patients and controls were 34.5 ± 8.5/mm2 and 11.2 ± 5.8/mm2, respectively, with the difference being highly significant (P 〈 0.001). These results suggest that increased cycling activity in a quantitatively unchanged CFU-Meg pool may lead to increased megakaryocytes in the bone marrow of ITP patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01732882
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