ISSN:
1619-7089
Keywords:
Key words: Somatostatin receptor-mediated internal radiotherapy
;
DTPA-d-Phe1-octreotide (OctreoScan)
;
DOTA-d-Phe1-Tyr3-octreotide (DOTATOC)
;
Indium-111
;
Yttrium-90
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. This study presents the first successful use of a peptidic vector, DOTATOC, labelled with the β-emitting radioisotope yttrium-90, for the treatment of a patient with somatostatin receptor-positive abdominal metastases of a neuroendocrine carcinoma of unknown localization. Tumour response and symptomatic relief were achieved. In addition, the new substance DOTATOC was labelled with the diagnostic chemical analogue indium-111 and studied in three patients with histopathologically verified neuroendocrine abdominal tumours for its diagnostic sensitivity and compared with the commercially available OctreoScan. In all patients the kidney-to-tumour uptake ratio (in counts per pixel) was on average 1.9-fold lower with 111In-DOTATOC than with OctreoScan. DOTATOC could be a potential new diagnostic and therapeutic agent in the management of neuroendocrine tumours.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00879669
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