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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 281 (1989), S. 279-283 
    ISSN: 1432-069X
    Keywords: Cutaneous candidiasis ; Epidermal proliferation ; Neutrophils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A mouse model of cutaneous candidiasis was used to determine if the prominent neutrophilic infiltrates in the infected skin of nonimmune animals were responsible for inducing the early phase of epidermal proliferation seen in these infections. Both the organisms and resulting neutrophilic microabscesses were found in the cellular layers of the epidermis at 12 h after inoculation, and were then extruded together to a more superficial site in the stratum corneum over the next 1–2 days. The degree of epidermal proliferation elicited at the site of the Candida foci, as determined from the thickness of the cellular layers of the epidermis, was the same for foci with neutrophils as for those without, even when the latter came from severely leukopenic animals. The location of neutrophils within the infected skin or the numbers of organisms present did not seem to make a difference with respect to the degree of epidermal proliferation produced at the site of Candida foci. These data suggest that in acute experimental cutaneous Candida infections the organisms can elicit a vigorous epidermal proliferative response in the absence of the neutrophilic infiltrates usually seen in these infections.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 43 (1998), S. 2715-2718 
    ISSN: 1573-2568
    Keywords: IRRITABLE BOWEL SYNDROME ; SYMPTOMS ; FREQUENCY ; DURATION ; SEVERITY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined symptom frequency, duration, andseverity, as well as episode patterns, in 122 adultpatients with irritable bowel syndrome in a 12-weekstudy conducted in the United States, the UnitedKingdom, and The Netherlands. Patients used aninteractive telephone data entry system daily to reportsymptoms. Data from 59 of the patients meeting inclusioncriteria are presented, the remainder having beenexcluded for failing to complete at least 70 days ofsymptom reporting. The majority of patients experiencedat least one symptom on over 50% of the reported days;however, individual symptoms were reported on less than 50% of the days, indicating that symptomssometimes occurred sequentially rather than alwayssimultaneously. On average, patients reportedpain/discomfort on 33% of days, bloating on 28% of thedays, altered stool form or stool passage on 25% and18% of the days, respectively, and mucus on 7% of thedays. The duration of symptoms was relatively short,with pain/discomfort and bloating lasting the longest, an average of five days each per episode. Allsymptoms but one (mucus) were moderately severe on themajority of reported days. Patients experienced an“episode” (defined as a period of days withsymptoms bounded by one or more symptom-free days) on anaverage of 12.4 times during the study, but the durationof these episodes varied greatly among patients. Theseresults further establish the chronic nature of irritable bowel syndrome and the burden thatthis condition imposes on patients.
    Type of Medium: Electronic Resource
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