ISSN:
1432-1912
Schlagwort(e):
Muscle Endplate
;
Denervation
;
Acetylcholinesterase
;
Decamethonium
;
Oholinergic Receptor
;
Muskelendplatte
;
Denervation
;
Acetylcholinesterase
;
Decamethonium
;
cholinergischer Receptor
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Using contact-autoradiography of the whole mouse diaphragm, the distribution of14C-labelled decamethonium during the degeneration of the phrenic nerve was investigated, and compared with cholinesterase staining. Four days after denervation uniform radioactivity is found over the whole muscle which is independent of the duration of the denervation, whereas in the control (right half of the diaphragm with intact phrenic nerve) the radioactivity remains concentrated in the endplate area. The distribution of the radioactivity is independent of the cholinesterase concentration. Quantitative densitometer measurements give a higher molecule count per endplate for decamethonium than for curare, which corresponds with the diffuse distribution of the cholinergic receptors in the endplate region.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00997644
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