ISSN:
0009-2940
Keywords:
Vanadium
;
Cryptands
;
Ionophors
;
Phosphatases
;
Decavanadate
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Treatment of a C222-vanadyl-AMP complex (C222 = cryptand-222, AMP = adenosine monophosphate) with Me2NH in the presence of air yielded centrosymmetric dihydrogen-decavanadate H2V10O428, sandwiched by two diprotonated C222 molecules. An X-ray crystal-structure analysis was performed of this compound with the overall composition [C222(H+)2]2[H2V10O28] · 2 1/2, H2O. Protonation sites in the anion are μ2-oxygen atoms linking two different vanadium centres. Protonation sites at the cryptand are the nitrogen and/or oxygen atoms of one of the -[CH2]2O[-CH2|2O|CH2]- bridges. The relevance of the compound for the stabilisation and transport of the kinase and phosphatase inhibitor decavanadate by biogenic ionophores is addressed.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19971300814
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