ISSN:
0170-2041
Keywords:
Oasomycin
;
Metabolites, secondary
;
Macrolactone
;
Desertomycin
;
Chemical screening
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
New macrolactones, named oasomycin A to D (1 to 4), were discovered by a chemical screening in the culture broth of Streptoverticillium baldacii subsp. netropse (strain FH-S 1625). The structures were established by detailed spectroscopic analysis. The fundamental 42-membered lactone moiety of oasomycin A and B (1 and 2) is analogous to that of desertomycin A (5), while the oasomycins C and D (3 and 4) are the first representatives of macrolactones bearing a 44-membered skeleton. These metabolites can be distinguished by side chain modifications at C-41 or C-43 as well as the presence of an α-linked D-mannose moiety attached to 22-OH. Due to the structural similarities the oasomycins are integrated into the desertomycin family. In vitro testing by using the HEP-G2 cell assay showed oasomycin A (1) to be an inhibitor of de novo cholesterol biosynthesis.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199319930193
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