ZIB

Hits per page

hit 1 - 1 | 1 hit

Sorting

Electronic Resource

Structure-based drug design (SBDD): Every structure tells a story... (1993)

Reich, Siegfried H. ; Webber, Stephen E.

Springer

Perspectives in drug discovery and design 1 (1993), S. 371-390

add to mindlist on the mindlist

Details

ISSN: 1573-9023

Keywords: Structure-based ; Design ; Crystallography ; Receptor ; Binding ; Inhibitor

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Summary In this article we report how protein-ligand X-ray structures can be used to identify and develop new drug candidates. The structure-based drug design approach (SBDD) is described, illustrating the way crystallographic information is utilized in an iterative manner to identify and optimize novel lead compounds, thereby accelerating the overall drug discovery process. The requirements for the effective use of SBDD and its implementation, drawing upon case histories from our Thymidylate Synthase (TS) research program, are described.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02174536

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

hit 1 - 1 | 1 hit