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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 137-146 
    ISSN: 1433-8491
    Keywords: Dexamethasone suppression test ; Psychiatric disorders ; Intervening variables ; Dexamethason-Suppressions-Test ; Psychiatrische Erkrankungen ; intervenierende Variable
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den letzten Jahren wurde in zahlreichen Publikationen der Dexamethason-Suppressions-Test (DST) als geeignetes Instrument zur Diagnostik endogener Depressionen dargestellt. Eigene Untersuchungen an 333 psychiatrischen Patienten und 121 gesunden Kontrollpersonen sprechen gegen eine differentialdiagnostische Wertigkeit des DST. Diese Aussage wird durch neuere Befunde anderer Arbeitsgruppen gestützt. Diagnoseunabhängige Variable wie Schweregrad der Erkrankung, Gewichtsverlust, Schlafstörungen, situativer Stress, Medikamenten- und Alkohol-Entzug sowie die Pharmakokinetik von Dexamethason scheinen entscheidend das Testergebnis zu beeinflussen.
    Notes: Summary In the past few years there have been numerous publications, which have stressed the value of the Dexamethasone Suppression Test (DST) as a diagnostic marker of endonous depression. Our own studies in 333 psychiatric inpatients and 121 healthy subjects did not reveal a differential diagnostic use for the DST. This result is in good agreement with recent results published in the literature. Our own data demonstrate, however, that intervening variables, such as severity of illness, weight loss, sleep disturbances, situational stress, drug and alcohol withdrawal and the pharmacokinetics of dexamethasone, have an important influence on the DST results, regardless of the diagnostic classification.
    Type of Medium: Electronic Resource
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