ISSN:
1432-2072
Schlagwort(e):
Drug discrimination
;
Ethylketocyclazocine
;
Bremazocine
;
Nalorphine
;
Pentazocine
;
Buprenorphine
;
Etorphine
;
Dextrorphan
;
Phencyclidine
;
Ketamine
;
Haloperidol
;
Diazepam
;
Pentobarbital
;
Rat
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract The purpose of this study was to evaluate the discriminative stimulus properties of some narcotic and nonnarcotic drugs in rats trained to discriminate the effect of the proposed opiate ϰ-receptor agonists ethylketocyclazocine and bremazocine. Male Sprague-Dawley rats were trained in a two-lever food-reinforced paradigm to discriminate between the effect of ethylketocyclazocine (0.32 mg/kg) or bremazocine (0.04 mg/kg) and saline. Both groups of trained rats showed dose-dependent generalization to the effect of the proposed ϰ-agonist MRZ-2033 and some animals generalized the effect of nalophine and pentazocine. Some ethylketocyclazocine — but no bremazocine — trained rats generalized the effect of buprenorphine. The effect of dextrorphan, phencyclidine, and ketamine was generalized by some bremazocine-, but no ethylketocyclazocine-trained rats. Neither group of rats generalized the effect of etorphine, haloperidol, diazepam, or pentobarbital. These data suggest the usefulness of this procedure to evaluate the ϰ-like properties of opioid drugs.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00470590
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