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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 30 (1991), S. 109-117 
    ISSN: 1436-6215
    Keywords: Guar gum ; serumlipids ; mechanism ; dietarycarbohydrate ; sucrose ; Guar Gum ; Serumlipide ; Mechanismus ; Diätkohlenhydrat ; Saccharose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Untersuchung wurde bei Miniaturschweinen der Effekt von Guar Gum auf die Serumlipide bei gleichzeitiger Gabe von entweder 50,3% Stärke oder 50,3% Saccharose untersucht. Dazu durchliefen 5 adulte hypercholesterolämische Miniaturschweine (Gesamtserumcholesterol 9,0 mmol/l) jeweils nach einer Cross-over-Anordnung 3 Versuchsreihen von Fütterungsexperimenten mit jeweils 8 Wochen Dauer. (Experiment I = Maisstärke plus 15 g Guar; Experiment II = Maisstärke plus 30 g Guar; Experiment III = Saccharose plus 30 g Guar pro Tag.) In Gegenwart von Maisstärke in der Diät hatten weder 15 g noch 30 g Guar Gum einen Einfluß auf die Serum-Cholesterin- oder -Triglyceridspiegel. Die Cholesterinkonzentration in den Lipoproteinfraktionen war während der Experimente I und II ebenfalls nicht signifikant beeinflußt. War hingegen Saccharose in der Diät enthalten, so senkte Guar den Serum-Cholesterinspiegel um ca. 20% (p 〈 0,01) (Experiment III). Bei dieser Diät konnte die Zulage von 30 g Guar pro Tag ebenfalls die Cholesterinkonzentration in den VLDL- und HDL-Fraktionen signifikant (p 〈 0,05) herabsetzen. In Experiment III konnte auch eine tendenzielle Reduktion des Cholesterins in der LDL-Fraktion gemessen werden. Die Untersuchung zeigt, daß Guar Gum einen hypocholesterolämischen Effekt in Gegenwart von Saccharose in der Diät entfaltet, nicht aber bei Stärke als Kohlenhydrat in der Diät.
    Notes: Summary We examined the effect of guar gum on serum lipids if fed together with either 50.3% starch or 50.3% sucrose in a balanced diet to pigs. For this purpose, five adult hypercholesterolemic minipigs (total serum cholesterol 9.0 mmol/l) underwent three consecutive 8-week crossover (control or guar supplementation) feeding experiments (experiment I = cornstarch plus 15 g guar, experiment II = cornstarch plus 30 g guar, experiment III = sucrose plus 30 g guar per day). With the cornstarch-based diet neither 15 g nor 30 g guar gum had an influence on serum total cholesterol or triglyceride levels. Also, the cholesterol concentrations in the lipoprotein fractions did not change significantly during experiments I and II, yet total serum cholesterol concentration was about 20% lower (p 〈 0.01) when guar gum was added to the sucrose diet in experiment III. In the presence of sucrose the supplementation of 30 g guar led to a significant decrease (p 〈 0.05) of the cholesterol concentrations in the very low-density lipoproteins (VLDL) and high-density lipoproteins (HDL). There was also a tendency for decreased cholesterol levels in the low-density lipoproteins (LDL) after adding 30 g guar to the sucrose diet. Thus, the study demonstrates that guar gum exerts a hypocholesterolemic effect in the presence of sucrose in the diet, but not in the case of starch consumption.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 135-143 
    ISSN: 1432-1440
    Keywords: Serum cholesterol ; Nutrition ; Dietary protein ; Thyroxine ; Mechanism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different dietary proteins determine different serum cholesterol levels if fed in a semisynthetic diet to some, but not all, animal species. In one species, the rabbit, this metabolic response is elicited without adding high sucrose or cholesterol supplements that have to be added to rat or pig diets in order to cause a similar response. Eleven out of 13 studies show that casein and soy protein do not induce different serum cholesterol levels in normal man. More important, protein-induced differences of serum cholesterol concentrations have not been reported when appropriate nutritional methodology has been applied. We conclude that no protein-induced hypercholesterolemia is observed in primates, particularly not in the human species. Dietary recommendations urging the general public to reduce consumption of animal protein because of a higher atherogenicity are not supported by the present data. The biochemical basis of the metabolic responses has been studied by many investigators, but no convincing unifying concept has yet been identified. The recent observation of higher serum thyroxine concentrations following soy protein consumption (and vegetable protein in general) when compared to casein shed new light on this problem. This endocrine response explains a wide array of metabolic features of soy-fed rodents: the lower hepatic VLDL secretion, the higher hepatic HMG-CoA reductase activity, the higher hepatic apo B, E receptor activity, the higher fecal bile acid excretion, and finally the lower serum cholesterol concentrations.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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