ISSN:
1432-1440
Keywords:
Doppler sonography
;
Peripheral vascular disease
;
Diabetic foot
;
Neuropathy
;
Reactive hyperemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Doppler sonographic examination of 51 diabetic subjects showed that the macrovascular hyperemic response of the pedal blood flow was negatively correlated to the duration of the disease (p〈0.01). In comparison with non-diabetic controls (n=20), the response was increased by more than 210% in newly detected diabetics, but decreased by more than 20% in long-term diabetics. Vascular response was correlated also not only to the duration of the diabetes, but to peripheral neuropathy (p〈0.001). The hyperemic response was reduced in patients with reduced nerve conduction time, or somatic neuropathy (142+152%,p〈 0.005), and in patients with reduced arterial pulsation, or autonomic neuropathy (152+88,p〈 0.005), both in comparison with non-diabetic controls (293±108%). The frequency of decreased macrovascular hyperemic response was in agreement with somatic neuropathy in 69.7% and with autonomic neuropathy in 75.8% of all patients. The results demonstrate that the macrovascular hyperemic response of blood flow in diabetic feet is already reduced at an early stage of peripheral neuropathy without peripheral vascular occlusive disease. The functional reduction of pedal blood flow may be important for the development of diabetic foot gangrene.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01660955
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