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  • 1
    ISSN: 1432-0460
    Keywords: Gastroesophageal reflux disease ; Diagnosis ; pH monitoring ; Diagnostic studies ; Deglutition ; Deglutition disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastroesophageal reflux disease (GERD) is one of the most frequent benign diseases of the gastrointestinal tract and in some cases the diagnosis may be very difficult. There are many diagnostic procedures but none of them could prove or definitely exclude the disease. The 24-h pH-monitoring is the “gold standard” for detection of gastroesophageal reflux and in many patients the reflux correlates with the GERD. The evaluation of a diagnostic method has to be done in a similar manner to the evaluation of therapeutic study (phase 1 to phase 4). For the definition of the “gold standard” for detection of a special diagnosis (e.g., the gastroesophageal reflux disease), the results of phase 3 studies for different methods had to be compared. The method with the best values for sensitivity and specificity is yet to be discovered. Until now, pH monitoring has been the gold standard for the diagnosis of GERD. However, there are many problems connected with using this method in clinical practice.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0385
    Keywords: Key words: Neuroendocrine tumor ; Carcinoid ; Diagnosis ; Therapy ; Gastrointestinal tract. ; Schlüsselwörter: Neuroendokriner Tumor ; Carcinoid ; Therapie ; Diagnostik ; Gastrointestinaltrakt.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. In der vorliegenden Arbeit wird unter Einbeziehung der aktuellen Klassifikation der neuroendokrinen Tumoren des Gastrointestinaltrakts und des Pankreas eine stadiengerechte Therapie vorgeschlagen. Grundsätzlich wird für alle neuroendokrinen Tumoren eine primäre chirurgische Therapie empfohlen, auch bereits bei bestehender Metastasierung. Besondere Bedeutung hat insbesondere bei Tumoren des oberen Gastrointestinaltrakts und des Pankreas eine adäquate präoperative klinische und pathohistologische Diagnostik. Wir haben versucht die therapeutischen Richtlinien analog der Klassifikation zu vereinfachen und zu präzisieren. Es wird in vielen Fällen jedoch unabdingbar sein, eine enge Kooperation zwischen Gastroenterologen, Chirurgen und Pathologen zu pflegen, um im individuellen Fall die adäquate Therapie zu finden.
    Notes: Summary. In this review therapeutic strategies for neuroendocrine tumors of the gastrointestinal tract and the pancreas are proposed, based on the recent classification. Generally, for all neuroendocrine tumors even with obvious metastases, surgery is recommended. Particularly for neuroendocrine tumors of the upper intestinal tract and the pancreas an extensive preoperative clinical and histopathological diagnosis is required. We tried to simplify the therapeutic strategies according to the classification; in several cases, however, very close cooperation between gastroenterologists, surgeons and pathologists is necessary to decide on the appropriate therapeutic strategy.
    Type of Medium: Electronic Resource
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