ISSN:
1432-1041
Keywords:
Digitalis
;
metabolism
;
excretion
;
enterohepatic recirculation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The metabolism of tritiated peruvoside was investigated in 4 subjects, one of whom had a biliary fistula. The serum half life of radioactivity and urinary, fecal and biliary excretion were measured. Similar amounts of radioactivity were excreted in urine after oral and intravenous administration. The total excretion in 48 h was similar in all subjects (32.9% to 37.1% of dose administered). No unchanged drug was detected in the urine by GLC/MS/MID. Two metabolites, A and B, appeared in the excreta, B being cardio-inactive. Although large amounts of radioactivity were excreted in bile, no evidence was found of enterohepatic recirculation of the drug
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00561747
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