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  • 1
    Electronic Resource
    Electronic Resource
    Radioimmunoassay of plasma digoxin in nephrotic syndrome (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 187-188 
    Details
    ISSN: 1432-1440
    Keywords: Radioimmunoassay ; Digoxin ; Digitalis ; Nephrotisches Syndrom ; Hypoproteinämie ; Radioimmunoassay ; Digoxin ; Nephrotic syndrome ; Hypoalbuminemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Plasma digoxin was determined by three different radioimmunoassays in blood samples from 12 patients with hypoalbuminemia before and after increasing the concentration of albumin and TBG. With the Clinical-Assays-[125I]-Kit and the Schwarz/Mann-[3H]-Kit reliable digoxin values were obtained even in patients with severe nephrotic syndrome.
    Notes: Zusammenfassung Mit drei verschiedenen Radioimmunoassays wurde die Digoxin-Konzentration im Plasma von 12 Patienten mit Hypoalbuminämie vor und nach Erhöhung der Albumin- und TBG-Konzentration bestimmt. Die Messungen mit dem Clinical-Assays-[125I]-Kit und dem Schwarz/Mann-[3H]-Kit ergaben auch bei Patienten mit schwerem nephrotischem Sydrom zuverlässige Werte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468885
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolism of peruvoside in man (1972)
    Springer
    European journal of clinical pharmacology 5 (1972), S. 65-71 
    Details
    ISSN: 1432-1041
    Keywords: Digitalis ; metabolism ; excretion ; enterohepatic recirculation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The metabolism of tritiated peruvoside was investigated in 4 subjects, one of whom had a biliary fistula. The serum half life of radioactivity and urinary, fecal and biliary excretion were measured. Similar amounts of radioactivity were excreted in urine after oral and intravenous administration. The total excretion in 48 h was similar in all subjects (32.9% to 37.1% of dose administered). No unchanged drug was detected in the urine by GLC/MS/MID. Two metabolites, A and B, appeared in the excreta, B being cardio-inactive. Although large amounts of radioactivity were excreted in bile, no evidence was found of enterohepatic recirculation of the drug
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561747
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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