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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 20 (1992), S. 281-284 
    ISSN: 1434-0879
    Keywords: Prostate fluid ; Testosterone ; Dihydrotestosterone ; Zinc ; Benign prostatic hyperplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to determine whether the androgen profiles of the prostate fluid (EPS) mirror the concentrations in the prostate tissue, we have measured testosterone and dihydrotestosterone (DHT) in EPS and correlated their levels to the concentrations found in hyperplastic prostate tissue (BPH) obtained from the same 19 patients. Although androgen concentrations in EPS were very high (testosterone=106.7±81.9 ng/g dry weight; DHT=54.2±11.2 ng/g dry weight), they did not reflect the concentrations measured in BPH tissue (testosterone=7.56±1.54 ng/g dry weight; DHT=10.54±0.63 ng/g dry weight). Additionally the accumulation of tissular DHT usually associated with BPH was not mirrored in the EPS specimens which demonstrated a relatively higher concentration of testosterone when compared to DHT. In EPS, there was also a very strong correlation between testosterone and DHT concentrations (r=0.89; P〈0.01). We have also measured zinc concentrations in EPS and BPH tissue but were unable to detect any relationship between the two parameters. Significantly, however, EPS zinc concentrations showed a close correlation with EPS testosterone (r=0.73; P〈0.01) and DHT (r=0.69; P〈0.01) concentrations.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 31 (1993), S. HTA3 
    ISSN: 1741-0444
    Keywords: Biomedical engineering ; Cost-effectiveness analysis ; Methodological rigour ; Policymaking ; Quality of life ; Technological innovation ; Technology assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The goals of biomedical engineering include the improvement of health and life quality of mankind. However, the contribution of biomedical engineering to those worthy ends must be more clearly related. Biomedical engineers should become more active in demonstrating to policymakers and other parties in healthcare the value of the contributions of healthcare technology. Technology assessment (TA) is a form of investigation designed to identify and evaluate the implications of technologies so as to inform policymaking. Among the important trends in TA that should be of special interest to biomedical engineers are the increasingly higher methodological standards for accepting evidence from clinical investigations, and the use of quality-of-life measures for determining how technologies affect people's lives.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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