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Digitale Medien

The effect of food on the movement of pellets in the gastro-intestinal tract (1989)

Kyroudis, Asterios ; Markantonis, Sophia L. ; Beckett, Arnold H.

Springer

Pharmacy world & science 11 (1989), S. 44-49

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Details

ISSN: 1573-739X

Schlagwort(e): Barium sulfate ; Biopharmaceutics ; Dissolution ; Food ; Lithium sulfate ; Pellets controlled release ; Radiography

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract The effect of food on the movement of pellets in the gastro-intestinal tract was investigated in seven volunteers, either by means of X-rays taken after oral administration of barium sulfate pellets or by means of saliva concentration profiles of lithium obtained after oral administration of lithium sulfate controlled-release pellets. The X-ray studies showed that food had an effect on the time required for the pellets to leave the stomach and on their degree of dispersion in the small intestine, but not on other parameters. The studies with the lithium sulfate controlled-release pellets showed that food had a significant effect only in one in three subjects.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01962974

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