ISSN:
1432-1041
Keywords:
Diuretic
;
drug interaction
;
gastrointestinal absorption
;
hydrochlorothiazide
;
propantheline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Hydrochlorothiazide 75 mg was given twice p.o. to fasting subjects. In the second study they had been pretreated with propantheline 60 mg. Plasma and urine concentrations of hydrochlorothiazide were determined by GLC. Pretreatment with propantheline on average delayed the maximal plasma level of hct from 2.4 to 4.8 h (p〈0.05); and the total urinary recovery of hydrochlorothiazide by 48 h was increased from 49.3 mg to 66.9 mg (p〈0.005). It was concluded that propantheline increased substantially the absorption of the diuretic.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00644613
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