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Digitale Medien

Scanning electron microscopy of changes in the urinary bladder in dogs treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) (1987)

Hirao, Y. ; Sasaki, K. ; Sanma, S. ; [weitere]

Springer

Urological research 15 (1987), S. 25-29

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ISSN: 1434-0879

Schlagwort(e): Scanning electron microscopy ; Dog ; Bladder cancer ; N-butyl-N-(4-hydroxybutyl)nitrosamine ; Chemical carcinogenesis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The fine structures of the bladder mucosa during BBN carcinogenesis and of bladder tumors induced by BBN in dogs were examined by scanning electron microscopy. Normal dog bladder mucosa was covered with polygonal superficial cells with peaked microridges, but no microvilli. Microridges and uniform microvilli were observed in hyperplastic mucosa. In low grade papillary tumors induced by low doses of BBN, pleomorphic microvilli predominated. In dogs which received high doses of BBN, bizarre pleomorphic microvilli and blebs were observed in papillary lesions, whereas bumpy surfaces with thick short microvilli were observed in non-papillary lesions. These sequential changes which were observed in dog bladder mucosa during BBN carcinogenesis parallelled the changes that occurred in the process of chemical carcinogenesis in rodents, and dog bladder tumors were similar to those of rodents and of human bladder cancers.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00256331

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Digitale Medien

Effects of various enzymes on the ability of hamster egg plasma membranes to fuse with spermatozoa (1978)

Hirao, Y. ; Yanagimachi, R.

New York, NY : Wiley-Blackwell

Gamete Research 1 (1978), S. 3-12

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Details

ISSN: 0148-7280

Schlagwort(e): Fusion ; Spermatozoa ; Eggs ; Golden hamster ; plasma membrane ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie

Notizen: To investigate which component of the plasma membrane of the hamster egg plays the central role in the sperm-egg fusion, the egg membrane was treated with a variety of proteolytic, carbohydrate-hydrolyzing, lipid-hydrolyzing, and other enzymes. The only enzyme that markedly effected the ability of the egg membrane to fuse with spermatozoa was phospholipase C. The lipid moieties of the egg plasma membrane (and possibly of the sperm membrane) must be of primary importance in sperm-egg fusion at fertilization.

Zusätzliches Material: 1 Ill.