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  • 1
    ISSN: 1437-3262
    Keywords: Micropalaeontology Palaeo-oceanography ; Plankton ; Sediment traps Recent and Holocene sediments ; Actualistic approach ; Norwegian-Greenland Sea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract A synoptic study is carried out to reconstruct the development of the plankton community in the late Quaternary in the Norwegian-Greenland Sea. It comprises quantitative analyses of coccolithophores, dinoflagellate cysts, diatoms and radiolarians. An actualistic approach is applied to evaluate the different fossil records of these plankton groups. The preliminary results of the current investigation are reported here. The composition and distribution of living communities of coccolithophores are presented as an example. A close relationship between the distribution of regional groups and surface water masses is observed. Seasonal vertical fluxes of coccolithophores and radiolarians through the water column show similar patterns within different years. However, diatoms are highly variable, both in absolute fluxes and species composition. The differentiation of sporadic and periodic processes is evident only after several years of observation. During settling and sedimentation biotic and abiotic processes such as grazing, dissolution and lateral transport alter the assemblages. Investigation of death assemblages in surface sediments reveals that in spite of these alteration processes the abundance and species distribution are related to surface water masses. Higher abundances and diversities are usually found in sediments underlying the warm Norwegian Current. Concentrations decrease to the north-west towards the cold polar water masses. The sediment assemblages of all groups are strongly altered relicts of former living communities. They are characterized by distinct changes in species composition and absolute abundances related to palaeo-oceanographic development. Their variation through the sedimentary record is used to distinguish four ecostratigraphic units during the late Weichselian and Holocene.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1459
    Keywords: Parkinson's disease ; Controlled release ; Levodopa ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five levodopa (l-dopa)-treated patients with Parkinson's disease with severe fluctuations of motor performance, plasma l-dopa as well as dopamine levels were measured during 2 days, first under optimal standard l-dopa with peripheral decarboxylase inhibitor (PDI) and then after a dose adjustment period using slow-release l-dopa/benserazide (Madopar HBS) in an open inpatient trial. Three patients benefited from the slow-release preparation; two patients deteriorated with a tendency to have an unpredictable response, a delay to turn “on” with the first dose in the morning, as well as an increase in dyskinesia corresponding to l-dopa cumulation during the day. These problems were subsequently also seen during the follow-up period of 1 year in those patients who benefited from Madopar HBS as inpatients. This might indicate that patient compliance is more difficult with the new formulation. After 1 year all patients had returned to their previous standard l-dopa/PDI treatment. l-Dopa levels continued to fluctuate, but to a lesser degree with Madopar HBS. The equivalent l-dopa dosage had to be increased by 56% (29–100%) with Madopar HBS while mean dopamine levels increased in four patients (by 47–257%) without the occurrence of peripheral side-effects. This implies that with the new formulation more l-dopa is metabolized to dopamine and explains the necessity to increase the equivalent l-dopa dosage.
    Type of Medium: Electronic Resource
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