Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Radioreceptor binding reveals the potencies of N,N-disubstituted 2-aminotetralins as D2 dopamine agonists (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 336 (1987), S. 487-493 
    Details
    ISSN: 1432-1912
    Keywords: 2-Aminotetralins ; N-0434 ; N-0437 ; 3H-Spiperone ; D2 Receptor ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The affinity of a series of N,N-disubstituted 2-aminotetralins for the rat striatal D2 dopamine receptor labelled by [3H]spiperone has been determined. Displacement data for the more potent 2-aminotetralins were better described by a model where the compounds competed for [3H]spiperone at two sites. The high affinity component accounted for approximately 80% of the total sites. Displacement curves for all 2-aminotetralins were shifted to the right by 100 μM guanosine-5′-triphosphate; a result attributable to the redistribution of 13–47% of the sites to a low affinity form. These data are consistent with the N,N-disubstituted 2-aminotetralins being agonists at the D2 dopamine receptor. In particular, the affinities of the 5-hydroxy-2-aminotetralins were as high as those of traditional dopamine agonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169304
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Differential effects of IV and IP muscimol on central dopamine metabolism (1981)
    Springer
    Psychopharmacology 74 (1981), S. 71-73 
    Details
    ISSN: 1432-2072
    Keywords: Muscimol ; Dopamine ; DOPAC ; Nigrostriatal ; Mesolimbic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of IV and IP muscimol on the concentrations of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in both the nigrostriata) and mesolimbic dopaminergic pathways has been studied. IV muscimol (2 mg/kg), produced significant decreases in the concentration of DA in both DA systems, while the concentration of DOPAC remained unaltered. However, IP muscimol (5 and 10 mg/kg) caused significant increases in the concentrations of DA or DOPAC in all brain regions examined. Our results suggest differential actions of muscimol on DA metabolism dependent upon the route of administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431760
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...