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  • 1
    Digitale Medien
    Digitale Medien
    Stimulation of a dopamine-sensitive adenylate cyclase in homogenates of rat striatum by a metabolite of piribedil (ET 495) (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 282 (1974), S. 213-216 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Piribedil ; Dopamine ; Cyclic AMP ; Striatum ; Parkinsonism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The addition of dopamine (1–100μM) to homogenates of rat striatum incubated with ATP evoked a 120% increase in the rate of cyclic 3′5′ adenosine monophosphate (cyclic AMP) production. The effects of added dopamine were mimicked by the addition of the compound S 584 [1-3,4-(dihydroxybenzyl)-4-(2-pyrimidinyl) piperazine] (1–100 μM), a catechol metabolite of the dopaminergic stimulant drug piribedil (ET 495). The latter substance was itself inactive in this system at these concentrations. The stimulation of cyclic AMP production by dopamine and by S 584 was potently inhibited by the dopamine antagonist dru chlorpromazine and spiroperidol (1–10 μM). It is possible that the dopaminergic effects elicited by piribedil may be mediated through the active metabolite S 584.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00499035
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of GABA, dopamine, and substance P on the release of newly synthesized 3H-5-hydroxytryptamine from rat substantia nigra in vitro (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 271-275 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Substantia nigra ; 5-Hydroxytryptamine ; α-Flupenthixol ; Substance P ; Dopamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of GABA, substance P and dopamine on the release of newly synthesized 3H-5-HT were investigated, using slices of rat substantia nigra superfused with l-3H-tryptophan in vitro. GABA (50 μM) had no inhibitory effect on the potassium-evoked-release of 3H-5-HT. Substance P (50 μM) and eledoisin (50 μM) stimulated the spontaneous release of 3H-5-HT. This effect seems to be indirect and is possibly mediated by dopaminergic neurones, since the dopamine antagonist drug α-flupenthixol (1 μM) abolished the substance P-evoked release of 5-HT. Furthermore, it was found that substance P (10 μM) stimulated 3H-dopamine release from nigral slices in vitro and the dopaminergic agonist apomorphine (50 μM) also stimulated 3H-5-HT release. Substance P may, therefore, activate nigral dopaminergic neurones which then release dopamine from their dendrites. The release of dopamine may in turn stimulate 5-HT release from terminals of the raphe-nigral pathway.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00507968
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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