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  • 1
    Electronic Resource
    Electronic Resource
    Islet cell antibodies in the Japanese population and subjects with Type 1 (insulin-dependent) diabetes (1985)
    Springer
    Diabetologia 28 (1985), S. 660-662 
    Details
    ISSN: 1432-0428
    Keywords: Population survey ; islet cell antibody ; Type 1 diabetes ; autoantibodies ; pre-Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islet cell antibodies were studied in 1,112 non-diabetic adults, 473 normal school children and 162 Type 1 (insulin-dependent) diabetic patients in a Japanese population. The prevalence of islet cell antibodies was 0.5%, 0.4% and 32%, respectively. Most islet cell antibodies positive subjects with Type 1 diabetes had short duration of the disease. No patients who had over 10 years from the onset had islet cell antibodies. Six non-diabetic adults with islet cell antibodies were followed for 4 years. Only one with Hashimoto's thyroiditis showed a diabetic pattern in her oral glucose tolerance test. However, none developed overt insulin-dependent diabetes until 1984. Two out of these six subjects continued to be positive for both islet cell antibodies and antithyroid antibodies or antinuclear antibodies. Islet cell antibodies in the remaining four patients disappeared during the second year. It is difficult to predict the onset of Type 1 diabetes by islet cell antibodies in non-diabetic individuals because they may be transient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291971
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential effects of three dopamine receptor agonists in MPTP-treated monkeys (1995)
    Springer
    Journal of neural transmission 10 (1995), S. 55-62 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine receptor agonists ; Parkinson's disease ; parkinsonism ; hyperactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behavioral effects of cabergoline, pergolide and bromocriptine were investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian cynomolgus monkeys with attention to the induction of hyperactivity, as evidenced by irritability, excitability and aggressiveness. All three drugs improved the parkinsonism in a dose-dependent fashion following a single injection. Among the three dopamine (DA) receptor agonists used, the antiparkinsonian effect of pergolide was the strongest and had an immediate effect, while cabergoline showed the longest duration of the antiparkinsonian effect and was least potent in inducing hyperactivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02256629
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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