ISSN:
1435-1463
Keywords:
Dopamine receptor agonists
;
Parkinson's disease
;
parkinsonism
;
hyperactivity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The behavioral effects of cabergoline, pergolide and bromocriptine were investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian cynomolgus monkeys with attention to the induction of hyperactivity, as evidenced by irritability, excitability and aggressiveness. All three drugs improved the parkinsonism in a dose-dependent fashion following a single injection. Among the three dopamine (DA) receptor agonists used, the antiparkinsonian effect of pergolide was the strongest and had an immediate effect, while cabergoline showed the longest duration of the antiparkinsonian effect and was least potent in inducing hyperactivity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02256629
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