ISSN:
1432-2072
Keywords:
Double-blind
;
Sulpiride
;
Chronic schizophrenic
;
Dosage regimens
;
Clinical effects
;
BPRS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In a study with both open and double-blind phases, a therapeutic response to sulpiride was first established in 18 chronic schizophrenic inpatients. Following this, two dosage regimens, a morning only dose, and the same daily total dose in two equal fractions at 8 a.m. and 4 p.m., were compared using a balanced design, crossover, placebo controlled study. Clinical effects were evaluated by means of the Brief Psychiatric Rating Scale (BPRS). There was a significant reduction in the mean BPRS score in all phases of the study. There was no significant difference between the mean BPRS scores resulting from the two dosage regimens. The study indicated that the two dosage regimens were equally efficacious.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00436165
Permalink
