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  • 1
    Electronic Resource
    Electronic Resource
    Discriminative stimulus properties of fenfluramine in an operant task: An analysis of its cue function (1977)
    Springer
    Psychopharmacology 53 (1977), S. 97-102 
    Details
    ISSN: 1432-2072
    Keywords: Fenfluramine ; Norfenfluramine ; Amphetamine ; Drug discrimination ; Stimulus properties of drugs ; Fixed ratio responding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fenfluramine at a dose of 3.0 mg/kg was found to possess discriminative stimulus properties controlling lever selection by rats in a two-lever operant task. Subjects trained to discriminate the ‘Fenfluramine cue’ failed to generalize to amphetamine in extinction tests at doses between 0.25 and 1.0 mg/kg. Subjects did, however, generalize to the fenfluramine metabolite, norfenfluramine, at a dose of 2.0 mg/kg. These data provide further evidence for a pharmacological difference between fenfluramine and amphetamine, and support the hypothesis that norfenfluramine is an active metabolite of fenfluramine. The relevance of these findings to theoretical and methodological aspects of drug discrimination studies is considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426700
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inter-animal olfactory cues in operant drug discrimination procedures in rats (1981)
    Springer
    Psychopharmacology 73 (1981), S. 363-371 
    Details
    ISSN: 1432-2072
    Keywords: Operant ; Drug discrimination ; Olfaction ; Methodology ; Nicotine ; Mecamylamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Olfactory cues from prior subjects in operant chambers were shown to be an effective stimulus which rodents could use to direct lever selection in a typical operant drug discrimination (DD) paradigm. Such cues persisted for very long periods of time (16h), and were deposited after very short (5 min) operant sessions. In extinction tests inter-animal olfactory cues exerted very strong stimulus control over lever selection. Furthermore, such cues were not specific to individual rodent subjects but were generalizable between subjects. Inter-animal cues directing lever selection could be abolished by cleaning operant manipulanda with a 10% alcohol solution. Reanalysis of some DD data previously reported by one of the authors (Goudie 1977) indicated that this specific earlier study (and by implication perhaps other studies) might have been confounded by inter-animal cues. In a DD study with nicotine it was found that the drug cue was antagonized by mecamylamine for all subjects except those who had a reliable olfactory cue from prior subjects to direct lever selection (subjects who possessed both an olfactory and a drug cue to direct lever selection responded in a way suggesting that the exteroceptive olfactory cue controlled behaviour rather than the interoceptive drug cue). These findings indicate that inter-animal olfactory cues could be of considerable methodological significance in DD studies. The possible significance of such cues has not previously been reported upon in detail, and in reports of many DD studies there do not appear to be explicit indications that interanimal cues have been adequately controlled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426467
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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