ISSN:
1619-7089
Keywords:
Dual-isotope single-photon emission tomography
;
Triple-energy window method
;
Iodine-123 BMIPP
;
Thallium-201
;
Coronary artery disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To improve the image quality in simultaneous dual-isotope single-photon emission tomography (SPET) with iodine-123 labelled 15-(p-iodophenyl)-3-methylpentadecanoic acid (BMIPP) and thallium-201, we applied the triple-energy window method JEW) for correction of the cross-talk and scatter artifact. Seventy-one patients with coronary artery disease were included.201T1 cross-talk into the123I acquisition window (group 1,n = 30) and123I cross-talk into the201Tl window (group 2,n = 41) were studied. In group 1,123I images were first obtained (single-isotope images), followed by201Tl injection and SPET acquisition using dual-isotope windows (dual-isotope images). In group 2, the order was reversed. The dual-isotope SPET images with and without TEW were compared with the single-isotope images. Qualitative evaluation was performed by scoring the segmental defect pattern. Detectability of the mismatched fatty acid metabolism on dual-isotope SPET was evaluated by receiver operating characteristic (ROC) curve analysis. Segmental defect pattern agreement between dual and corrected single images was significantly improved by TEW correction (P〈0.01). The agreement was particularly improved in segments with absence of uptake. There was no significant difference between TEW-corrected dual-isotope SPET and corresponding single-isotope SPET with regard to either % defect count or background activity. Mismatched fatty acid metabolism depicted by dual-isotope SPET predicted abnormal wall motion more accurately with TEW than without TEW. With TEW, a practical method for scatter and cross-talk correction in clinical settings, simultaneous dual123I-BMIPP/201Tl SPET is feasible for the assessment of myocardial perfusion/metabolism mismatch.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01254240
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