ISSN:
1432-069X
Keywords:
TPA
;
Protein kinase C
;
E5166
;
Retinoids
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 12-o-Tetradecanoylphorbol-13-acetate (TPA) activates calcium-activated, phospholipid-dependent protein kinase (protein kinase C) partially purified in an ion exchange column from pig epidermis. Protein kinase C was activated by TPA in a concentration-dependent manner with simultaneous addition of Ca2+ and phospholipid. Polyprenoic acid derivative (E5166) which is a newly synthesized retinoic acid derivative, inhibited the TPA activation of protein kinase C. This inhibition may explain the mechanisms by which retinoids inhibit TPA-induced tumor promotion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00404358
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