ISSN:
1432-069X
Keywords:
Epidermis
;
ETAF
;
Interleukin 1
;
Mixed skin lymphocyte reaction
;
Tuberculin skin test
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Forty-one persons were tested for tuberculin skin reactivity. Epidermal cells (ECs) were isolated from the tuberculin reaction and from a contra lateral, non injected skin area. We found a significant increase of epidermal thymocyte activating factor (ETAF) in epidermis overlying a positive tuberculin reaction together with an increase of OKT6 and class II (HLA-DR) positive cells. Allogeneic lymphocytes proliferated significantly more when mixed with ECs from a positive tuberculin skin test. Injection of tuberculin per se or a negative reaction did not induce similar changes. The described model seems useful for functional studies of ECs and lymphocytes in patients with contact dermatitis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00417709
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