ISSN:
1432-2013
Keywords:
Pancreatic islets
;
Electrical activity
;
Calcium
;
Potassium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A rise in extracellular glucose concentration from 8.3 to 16.7 mM stimulates both Ca2+ inflow and K+ exit in perfused rat pancreatic islets. These ionic changes are associated with an increase in bioelectrical spiking activity. From a quantitative analysis of45Ca and86Rb outflow from prelabelled islets, it is proposed that each electrical spike coincides, approximately, with the entry of 0.8 fmol of Ca2+ and exit of 3.6 fmol of K+ per mm2 of cell surface.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00584810
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