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  • 1
    Digitale Medien
    Digitale Medien
    How well can quantitative 24-hour intraesophageal pH monitoring distinguish various degrees of reflux disease? (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 1317-1324 
    Details
    ISSN: 1573-2568
    Schlagwort(e): reflux disease ; pH monitoring ; reflux esophagitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Twenty-four normal subjects and 64 symptomatic patients with various degrees of reflux disease (24 with reflux symptoms without esophagitis and 21 with mild and 19 with severe esophagitis) underwent quantitative 24-hr intraesophageal pH monitoring. Various reflux parameters during supine, interprandial, and postprandial periods were examined by binary logistic regression and by CART analysis to determine the sensitivity and specificity to separate the various groups of subjects and patients. The distinction was excellent between asymptomatic controls and patients with severe erosive esophagitis (sensitivity and specificity both 100% by logistic regression and 95% and 88%, respectively, by CART), but discrimination was poor when asymptomatic controls were compared to symptomatic patients without esophagitis (71% and 79% by logistic regression and 75% and 92% by CART), which is the most important indication for pH recording in clinical practice. A 3-hr postprandial pH recording was inadequate to distinguish the various groups. The acidity of the reflux episodes during the night appeared to be a crucial factor in the development of severe erosive esophagitis. The duration of esophageal acid exposure was another important factor in the development of reflux lesions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02065545
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  • 2
    Digitale Medien
    Digitale Medien
    Omeprazole (40 mg) is superior to ranitidine in short-term treatment of ulcerative reflux esophagitis (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 523-529 
    Details
    ISSN: 1573-2568
    Schlagwort(e): reflux esophagitis ; omeprazole ; ranitidine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The efficacy and safety of omeprazole, 40 mg once daily for four to eight weeks of treatment, were studied in 61 patients with ulcerative reflux esophagitis. A double-blind controlled study design was used, and the patients were randomly allocated to treatment with either omeprazole 40 mg once daily or ranitidine 150 mg twice daily. Endoscopy was performed prior to inclusion into the study, after four weeks and, if unhealed, again after eight weeks. Healing of esophagitis was defined as complete disappearance of all esophageal ulcerations. Symptoms were recorded before entry, after four weeks, and again after eight weeks in unhealed patients. Fifty-one patients were included in the per-protocol analysis at day 29, and 50 patients at day 57. The healing rate after four weeks of treatment was 22 of 26 patients (85%) treated with omeprazole and 10 of 25 patients (40%) treated with ranitidine (P〈0.001). The corresponding figures after eight weeks were 24 of 25 (96%), and 13 of 25 (52%) (P〈0.001). These results were confirmed in the intent-to-treat analysis. Patients treated with omeprazole showed a significantly faster and more profound relief in heartburn than patients treated with ranitidine: 85% had no heartburn after four weeks of treatment with omeprazole compared to 24% in patients treated with ranitidine (P=0.00007). The percentage of patients who were free of all reflux symptoms was significantly greater in the omeprazole-treated group as compared to the ranitidine-treated group (62% and 12% respectively, P=0.0001). There were no clinically significant changes in laboratory values in any of the treatment groups. Adverse events were few and mainly mild and transient.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01798351
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  • 3
    Digitale Medien
    Digitale Medien
    Adaptive method for cancellation of respiratory artefact in electrogastric measurements (1989)
    Springer
    Medical & biological engineering & computing 27 (1989), S. 57-63 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Adaptive filter ; Electrogastrography ; Noise cancellation ; Respiratory artefact
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Electrogastic measurements are useful for medical research and in clinical diagnosis. The measurements, however, contain very heavy respiratory artefact. Existing conventional frequency-domain filters cannot be used because of the possible overlap of the frequencies of the gastric signals and respiratory artefact. In the paper, the methods of measuring cutaneous and intraluminal gastric signals and reference respiratory signals are described. An adaptive cancellation technique is developed, which is simple and easy to implement for online processing. It is proved by experiments to be very efficient, i.e. the respiratory artefact can be completely cancelled, while the gastric signal component is not affected. Other possible applications in biomedical signal analysis are also discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02442170
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  • 4
    Digitale Medien
    Digitale Medien
    Adaptive spectral analysis of cutaneous electrogastric signals using autoregressive moving average modelling (1990)
    Springer
    Medical & biological engineering & computing 28 (1990), S. 531-536 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Autoregressive moving average modelling ; Electrogastrography ; Gastric motility ; Gastric slow wave ; Spectral analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract The recording of the human, gastric myoelectrical activity, by means of cutaneous electrodes is called electrogastrography (EGG). It provides a noninvasive method of studying electrogastric behaviour. The normal frequency of the gastric signal is about 0·05 Hz. However, sudden changes of its frequency have been observed and are generally considered to be related to gastric motility disorders. Thus, spectral analysis, especially online spectral analysis, can serve as a valuable tool for practical purposes. The paper presents a new method of the adaptive spectral analysis of cutaneous electrogastric signals using autoregressive moving average (ARMA) modelling. It is based on an adaptive ARMA filter and provides both time and frequency information of the signal. Its performance is investigated in comparison with the conventional FFT-based periodogram method. Its properties in tracking time-varying instantaneous frequencies are shown. Its applications to the running spectral analysis of cutaneous electrogastric signals are presented. The proposed adaptive ARMA spectral analysis method is easy to implement and is efficient in computations. The results presented in the paper show that this new method provides a better performance and is very useful for the online monitoring of cutaneous electrogastric signals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02442603
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  • 5
    Digitale Medien
    Digitale Medien
    Observation of the propagation direction of human electrogastric activity from cutaneous recordings (1989)
    Springer
    Medical & biological engineering & computing 27 (1989), S. 538-542 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Electrogastrography ; Gastric activity ; Phase shift
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Electrogastric signals have been successfully measured both intraluminally and cutaneously. although it has been claimed by several researchers that the propagation direction of the electrogastric activities cannot be observed from cutaneous recordings, it is the aim of the paper to show that it is feasible. The reason why the propagation direction has never been observed from cutaneous recordings is that the reported methods for the abdominal measurements are not adequate. In the paper it is pointed out that the stomach should be localised before the measurement and the electrodes should be attached along the longitudinal axis of the stomach.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441475
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